ANNOTATION

Crystallization is one of the most important separation/purification techniques in industrial production of chemicals and pharmaceuticals. The quality of product is dependent on the crystal size distribution. It is therefore beneficial for the companies to have a functional crystallization model based on population balances to optimize the process. Crystallization is strongly affected by the mixing conditions. To describe a semi-batch crystallizer, one must take into account the mixing process at all scales (macro, meso and microscale). Assumption of ideal mixing is not accurate as the concentration by the feed pipe can be noticeably different than in the bulk. The goal of this thesis is to develop a general model of semi-batch reactive and antisolvent crystallizer. Moreover, parametric analysis will be performed to study the crystallization process under qualitatively different conditions (fast/slow reaction vs fast/slow nucleation/growth rate etc.) for deeper understanding of the process.